ABSTRACT
The 1,2-bis(3,4-dimethoxybenzylidene)hydrazine (VAHD) and 1,2-bis(3-methoxy-4-hydroxybenzylidene)hydrazine (VNHD) are synthesised in a solvent free and catalyst free by greener method (MW). Both the compounds are characterized by FT-IR,1H NMR and 13C NMR spectral studies. Single crystal XRD analysis provides more information on the structure of the compounds VAHD and VNHD. The energy gap (Eg), frontier orbital energies (EHOMO, ELUMO) and reactivity parameters like chemical hardness and global hardness andMulliken charges are calculated using density functional theory with B3LYP/6-311++G(d,p) basis set. The experimental and theoretical calculated IR frequencies and NMR chemical shifts values are compared by DFT method. Hirshfeld surface analysis was conducted to study structure and molecular properties. Molecular docking of symmetrical azine at the active sites of SARS-COVID receptors was investigated. Furthermore, the swissADME online application was used to analyse the physicochemical and pharmacokinetic features of the compounds (VAHD and VNHD). © 2023 Wiley-VCH GmbH.
ABSTRACT
Objective: A novel coronavirus infection (SARS-CoV-2) pneumonia (COVID-19) has been quickly spreading throughout China and the rest of the world since December 2019. Respiratory tract infections are frequently linked to diabetes mellitus (DM), a different risk factor. This study has reported the clinical presentation and therapeutic outcomes of COVID-19 with diabetes. Method(s): From medical records and histories provided by 72 Covid-19-infected patients with diabetes admitted to the KMCH institute of health sciences and research, Coimbatore, data on demographics, clinical, laboratory, and radiological characteristics as well as treatment outcomes were collected using data collection forms. Real-time reverse transcription polymerase chain reaction (RT-PCR) assay of 2019-CoV RNA was used to screen patients with Covid-19. Result(s): 72 diabetes patients who tested positive for Covid-19 were admitted for this study. SPSS software version 26 was used to evaluate the data that had been collected. Clinical profiles and outcomes of patients with and without diabetes underwent descriptive analysis. Controlled diabetics had a mean plasma glucose of 112.22+/-11.41, while uncontrolled diabetics had a mean plasma glucose of 154.2+/-23.22. Fever was the most prevalent symptom in both managed and uncontrolled diabetes patients (94% and 100%), followed by sore throat (84% and 88%). In patients with uncontrolled diabetes compared to those with controlled diabetes, breathlessness is considerably higher (p<0.05). In the CORADS scoring, 11 of the 34 diabetics with uncontrolled blood sugar levels had CORADS 6 (32.35%), compared to just 2 of the 38 diabetics with regulated blood sugar levels (5.26%), which is considerably higher (p<0.01). In uncontrolled diabetics, the length of hospital stay is much longer (p<0.001). Compared to diabetics with controlled blood sugar, uncontrolled patients SPO2 dramatically dropped (p<0.001). Those with uncontrolled diabetes are more likely to be admitted to the ICU than patients with controlled diabetes (p<0.05). In uncontrolled diabetes compared to controlled patients, the severity was considerably higher (p<0.05). One person who had uncontrolled diabetes died, although no one who had controlled diabetes died. Conclusion(s): Covid 19, persons with uncontrolled diabetes appear to be more likely to sustain lung damage, necessitating admission to the ICU, an extended stay in the hospital, and oxygen assistance throughout the duration of the illness. Copyright © 2023 The Authors. Published by Innovare Academic Sciences Pvt Ltd.
ABSTRACT
Perhaps the worst predicament faced by humanity in the twenty-first century is the COVID-19 pandemic, which is caused by the SARS-CoV-2 virus. Most parts of the world, including India, went into lockdowns for some period because of the massive increase in cases throughout 2020. Face masks became an important counter-measure for protecting the populace, health professionals, and medics, particularly during the period prior to the mass availability of vaccines. This study intends to evaluate the effectiveness of face masks in limiting the spread of the virus. The data for the number of COVID-19 cases was analyzed from January 1, 2022 to May 31, 2022, using Python programming. This timeframe involved face mask mandates and no mask requirement, and hence was considered to be ideal for analyzing the usefulness of face masks. A decline in cases during the mandate was observed, while the opposite occurred without the mandate. The outcome of the research showed that face masks are effective additional measures against the spread of SARS-CoV-2. This study elevates the value of personal protective equipment (PPE), such as face masks, made with nonwovens and other fabrics, as lifesavers in the case of airborne diseases such as COVID-19 and other pulmonary disorders. Application: This study shows that extra precautions like wearing face masks helped stop the spread of SARS-CoV-2 along, with vaccinations. © TAPPI Press 2022.
ABSTRACT
Due to the shortage of personal protective equipment during the COVID-19 pandemic, homemade face coverings were recommended as alternatives. However, the capability of alternative face coverings to prolifer-ate microbes have not been fully documented. The current study evaluated bacterial load and proliferation associated with the use of common face masks dur -ing the COVID-19 pandemic. Mask type-specific and surface-related bacterial load and pattern were noticeable in the study. Results indicated that roadside masks are among samples that contained relatively higher initial bacterial load. The highest number of bacterial forming colonies were observed in the inner surface of mask samples. Proliferation of microbes over time was also noticeable among the non-certified face coverings included in the study. Sterilization or washing of non-certified fabric face masks before use is recommended. Application: Apart from protecting the wearer from getting exposed to the infection, face coverings also stop the spread from infected individuals. The present study examined the population of microbes distributed over the mask surface during use. The microbial load on each type of mask, the health, and potential safety risks were high-lighted. This information could guide policy and mitigating measures against severe acute respiratory syndrome (SARS) related infections.
ABSTRACT
Introduction: SARS-CoV-2 virus causes a pneumonia that was identified through fever, dyspnoea, and acute respiratory symptoms and named COVID-19. This disease exacerbates in a number of patients and causes pulmonary edema, multi-organ failure, and acute respiratory distress syndrome (ARDS). Prevalence of ARDS among COVID-19 patients has been reported to be up to 17%. In the absence of effective targeted therapies for COVID-19, optimisation of supportive care is essential. micro vascular thrombi, Lung injury with features of acute respiratory distress syndrome (ARDS) appears to be the principal characteristic of severe acute respiratory syndrome corona virus 2 infection Among treatment methods for management of ARDS patients, prone position can be used as an adjuvant therapy for improving ventilation in these patients Aim : To find out the beneficial effects of prone position ventilation in COVID-19 patients ARDS. Presently, no published trials investigate the effectiveness of prone positioning in awake patients with typical ARDS Material and methods: Patients admitted in various tertiary care COVID-19 hospitals in coimbatore are taken for study. totally 300 patients on ventilators, invasive and non invasive ventilation are taken for study. Study period 1 st March 2020 to 28 th February 2021.
ABSTRACT
The COVID-19 pandemic has been one of the biggest public health challenges of the 21st century. Many prevalent measures have been taken to prevent its spread and protect the public. However, the use of face coverings as an effective preventive measure remains contentious. The goal of the current study is to evaluate the effectiveness of face coverings as a protective measure. We examined the effectiveness of face coverings between 1 April and 31 December 2020. This was accomplished by analyzing trends of daily new COVID-19 cases, cumulative confirmed cases, and cases per 100,000 people in different U.S. states, including the District of Columbia. The results indicated a sharp change in trends after face covering mandates. For the 32 states with face covering mandates, 63% and 66% exhibited a downward trend in confirmed cases within 21 and 28 days of implementation, respectively. We estimated that face covering mandates in the 32 states prevented approximately 78,571 and 109,703 cases within 21- and 28-day periods post face covering mandate, respectively. A statistically significant (p = 0.001) negative correlation (-0.54) was observed between the rate of cases and days since the adoption of a face covering mandate. We concluded that the use of face coverings can provide necessary protection if they are properly used.
ABSTRACT
Background: Research information is required to create evidence-driven methodologies to decrease unfavourable mental impacts and psychiatric side effects amid the pandemic situation. Objective: This survey aimed to discover awareness level, behaviour, attitudes and also to analyze the psychological status related to coronavirus outbreak. Methods: The online survey was conducted by snowball examining methods. Results: This study included 520 respondents from different cities of Tamilnadu. 71% of the members are aware of the preven-tive measures. 48% of the members are with high fear and uneasiness since of this widespread circumstance in Tamilnadu. 52% of the members feel boredom, frustrated since of lost their open-air exercises. 72% of the participants feel a change of mood and behaviour. There is a positive correlation between change in sleep and eating pattern and time saved. Conclusion: During the various stage of COVID-19 episode in Tamilnadu the results are compared to the existing COVID-19 widespread outbreak;they gain access to awareness level, fear, emotional distress, as the affected persons are viewed as mod-erate. It is very important to take care of the mental welfare of the population and proactive steps to play down its inconvenient impacts amid the COVID-19 pandemic. © IJCRR.